Good News For Breast Cancer Patients, May Not Translate Well For Osteoporosis Patients Says Expert : RushPRNews - Newswire & Global Press Release Distribution

 
Bookmark and Share

Good News For Breast Cancer Patients, May Not Translate Well For Osteoporosis Patients Says Expert

July 22, 2009

Boonton, NJ - The news is optimistic for breast cancer patients in cases where the ailment has spread to the bones. A clinical test shows that Denosumab is better than an existing drug on the market in treating the bone ailment affecting these patients.

Denosumab is a fully human monoclonal antibody that specifically targets the receptor activator of nuclear factor kappa B ligand (RANKL), a key mediator of the resorptive phase of bone remodeling. Denosumab is being studied across a range of conditions, including osteoporosis, treatment-induced bone loss, rheumatoid arthritis, bone metastases, and multiple myeloma.

A biologics license application (BLA) has recently been submitted to the U.S. Food and Drug Administration for Denosumab to be used in the treatment and prevention of postmenopausal osteoporosis in women and treatment and prevention of bone loss among patients undergoing hormone ablation for breast or prostate cancer.

Previous studies have suggested that Denosumab may be better than bisphosphonates in preventing bone loss and skeletal complications in women with breast cancer. To directly compare Denosumab to another injectable bisphosphonate product among breast cancer patients with bone metastases, researchers conducted a Phase III clinical trial. The study enrolled more than two thousand patients. Study participants were assigned to receive either of the two drugs. Although the results show that Denosumab may be better at preventing the spread of cancer to the bones, the frequency of a well-known bone side effect was similar.

“For the millions of osteoporosis patients who are cancer-free and looking for convenient, safe alternatives to existing therapies, this product requires twice-yearly doctors’ visits for injection as compared to self-administered daily, weekly, or monthly pills or nasal sprays. Moreover, patients may suffer from the same type of side effect issues seen with some of the leading osteoporosis drugs,” warns bone expert Warren Levy, PhD, CEO of Unigene Laboratories.

Reports have associated certain bisphosphonates with osteonecrosis (i.e., “bone death”) of the jaw, severe bone/joint pain, sudden fractures that do not heal, irregular heart rhythms, esophageal cancer, renal failure and potentially severe gastrointestinal side effects.

Alternative categories of drugs have been shown to reduce fracture risk including calcitonin, parathyroid hormone, estrogen, selective estrogen receptor modulators and testosterone.

“Other products have been shown to help certain osteoporosis patients maintain proper bone density without these potential risks,” says Dr. Levy. “Denosumab shows tremendous potential to help breast cancer patients, but for many osteoporosis patients, this new discovery may have both pros as cons.” For more information, log on to www.unigene.com

Media Contact:
Janet Vasquez

The Investor Relations Group

212-825-3210

jvasquez@investorrelationsgroup.com

About the author:

Janet Vasquez, Director of Corporate Communications

About IRG

We are The Investor Relations Group (IRG), a full-service corporate communications firm that provides investor relations and public relations services to nano-, micro- and small-cap companies providing them with the equivalent in-house services of a large-cap company.

http://www.investorrelationsgroup.com

Click here to see all news from this author/company

Filed Under: Health and Fitness, PRESS RELEASE, BREAKING NEWS, FDA- Pharmaceutical news, MSN NEWS, Excite News

RUSH PR NEWS newswire and press release services at rushprnews.com / Anne Howard annehowardpublicist.com

Content- Legal Responsibility - All material is copyrighted - You may repost but you MUST link back to the original post on your page and acknowledge Rush PR News as the news source. Rush PR News is not legally and/or morally responsible for content of press releases, opinions expressed or fact-checking.

Rush PR News cannot be held legally responsible for material published and distributed through its newswire service or published in its press-room and therefore cannot be sued for published material. Third-party must be contacted directly to dispute content.

Rush PR News is not the contact for material published.

RSSFeed PRESS & SOCIAL MEDIA RELEASES

Coalition Joins National Coalition for Infant Health

Washington, D.C. 06/25/15 · Newborn Foundation News: Newborn Health leaders convene in DC...

RushPRnews now offers digital news sites +Targeted News outlet Broadcast

SAN FRANCISCO/MONTREAL 06/22/15 · Your press release to be featured on at...

Save our Skies Santa Cruz Launches Petition Urging FAA to Stop the Jet Noise

Santa Cruz, California 06/21/15 · Outraged Citizens fight FAA's NextGenprogram to reclaim quality...

Ultraseal International makes casting impregnation even easier with fully automated two-stage process

Dusseldorf, Germany 06/17/15 · Ultraseal International is living up to its global...

Army Officials and Ameresco Join to Commemorate Completion of Energy Efficiency and Solar Project

FRAMINGHAM, Mass. & ADELPHI, Md. 06/16/15 · Army Officials and Ameresco Join to Commemorate Completion...

Ultraseal International celebrates second exporting award this year

Birmingham, West Midlands, UK 06/16/15 · Ultraseal International is celebrating a double success after...

The American radio host, Ed Tyll issues death threat, alleges a French-Canadian publisher

Montreal, Quebec, Canada 06/15/15 · On June 5, the controversial radio host, Edward...

Planwise: Best Mortgage Calculator Since 1993

San Francisco, CA 06/09/15 · Planwise Launches Pinterest Style Mortgage Calculator  Planwise launches PlanwiseConnect,...

Israel’s Start Tel Aviv offers global opportunity for Canadian tech startups

Ottawa,Canada 06/09/15 · Israel’s Start Tel Aviv offers global opportunity for...

Demand for Independence of Punjab Echoes in San Francisco

San Francisco 06/08/15 ·  Thousands of North American Sikhs converged in downtown...

World Renowned Casting Director Appointed to Eagle Arts Academy Board of Directors

Los Angeles, CA 06/06/15 · Eagle Arts Academy is pleased to announce that...

MultiClonal Therapeutics Researchers Report Today Breakthrough in Cloning Human “Ground State” Stem Cells

Farmington,CT 06/05/15 · An international consortium including investigators at MultiClonal Therapeutics,...

Time to increase your public relations impact

SAN FRANCISCO 06/04/15 ·                 Your « SPRING2015-2 » Coupon is here! And with it...

Financial Fraud Lengthy Prison Term for Advance Fee Fraudster

Washington, DC 06/02/15 · Like many successful con men, William C. Lange...