Good News For Breast Cancer Patients, May Not Translate Well For Osteoporosis Patients Says Expert : RushPRNews - Newswire & Global Press Release Distribution

 
Bookmark and Share

Good News For Breast Cancer Patients, May Not Translate Well For Osteoporosis Patients Says Expert

July 22, 2009

Boonton, NJ - The news is optimistic for breast cancer patients in cases where the ailment has spread to the bones. A clinical test shows that Denosumab is better than an existing drug on the market in treating the bone ailment affecting these patients.

Denosumab is a fully human monoclonal antibody that specifically targets the receptor activator of nuclear factor kappa B ligand (RANKL), a key mediator of the resorptive phase of bone remodeling. Denosumab is being studied across a range of conditions, including osteoporosis, treatment-induced bone loss, rheumatoid arthritis, bone metastases, and multiple myeloma.

A biologics license application (BLA) has recently been submitted to the U.S. Food and Drug Administration for Denosumab to be used in the treatment and prevention of postmenopausal osteoporosis in women and treatment and prevention of bone loss among patients undergoing hormone ablation for breast or prostate cancer.

Previous studies have suggested that Denosumab may be better than bisphosphonates in preventing bone loss and skeletal complications in women with breast cancer. To directly compare Denosumab to another injectable bisphosphonate product among breast cancer patients with bone metastases, researchers conducted a Phase III clinical trial. The study enrolled more than two thousand patients. Study participants were assigned to receive either of the two drugs. Although the results show that Denosumab may be better at preventing the spread of cancer to the bones, the frequency of a well-known bone side effect was similar.

“For the millions of osteoporosis patients who are cancer-free and looking for convenient, safe alternatives to existing therapies, this product requires twice-yearly doctors’ visits for injection as compared to self-administered daily, weekly, or monthly pills or nasal sprays. Moreover, patients may suffer from the same type of side effect issues seen with some of the leading osteoporosis drugs,” warns bone expert Warren Levy, PhD, CEO of Unigene Laboratories.

Reports have associated certain bisphosphonates with osteonecrosis (i.e., “bone death”) of the jaw, severe bone/joint pain, sudden fractures that do not heal, irregular heart rhythms, esophageal cancer, renal failure and potentially severe gastrointestinal side effects.

Alternative categories of drugs have been shown to reduce fracture risk including calcitonin, parathyroid hormone, estrogen, selective estrogen receptor modulators and testosterone.

“Other products have been shown to help certain osteoporosis patients maintain proper bone density without these potential risks,” says Dr. Levy. “Denosumab shows tremendous potential to help breast cancer patients, but for many osteoporosis patients, this new discovery may have both pros as cons.” For more information, log on to www.unigene.com

Media Contact:
Janet Vasquez

The Investor Relations Group

212-825-3210

jvasquez@investorrelationsgroup.com

About the author:

Janet Vasquez, Director of Corporate Communications

About IRG

We are The Investor Relations Group (IRG), a full-service corporate communications firm that provides investor relations and public relations services to nano-, micro- and small-cap companies providing them with the equivalent in-house services of a large-cap company.

http://www.investorrelationsgroup.com

Click here to see all news from this author/company

Filed Under: Health and Fitness, PRESS RELEASE, BREAKING NEWS, FDA- Pharmaceutical news, MSN NEWS, Excite News

RUSH PR NEWS newswire and press release services at rushprnews.com / AH Marketing ahmarketinggroup.com

Content- Legal Responsibility - All material is copyrighted - You may repost but you MUST link back to the original post on your page and acknowledge Rush PR News as the news source. Rush PR News is not legally and/or morally responsible for content of press releases, opinions expressed or fact-checking.

Rush PR News cannot be held legally responsible for material published and distributed through its newswire service or published in its press-room and therefore cannot be sued for published material. Third-party must be contacted directly to dispute content.

Rush PR News is not the contact for material published.

RSSFeed PRESS & SOCIAL MEDIA RELEASES

$20 Off PR Events Coupon. Publish Your Press Release Today

San Francisco 05/31/16 · RushPRNews' motto is PR Made Easy, and we are...

High-Tech Bridge Uncovers Large Number Of Fraudulent Cybersecurity Company Domains

San Francisco, US/ Geneva, Switzerland 05/26/16 · Research into the proliferation of fraudulent domains affecting...

Compliance Map tracks Country of Origin in complex supply chains

Solihull, United Kingdom 05/26/16 · The Compliance Map, a developer of environmental compliance...

Fast Lane Announces Global IT Security Training Partnership with NotSoSecure

Morrisville, NC 05/25/16 ·  - Business news -  Fast Lane Announces Global IT...

Publishing A Magazine To iPad Is Affordable With Twixl Publisher

Santa Cruz, California 05/21/16 · Fear Not: Solution is at hand to combat...

Losode.com making an impression in Virgin Media’s #VOOM 2016

London, United Kingdom 05/19/16 · Losode.com making an impression in Virgin Media’s  #VOOM...

Wayne Gretzky named A Great Canadian for the Canada D’Eh Run

Amherstburg ON 05/18/16 · Participants Voted And They Have Chosen The Great...

VOTE for Losode.com, an innovative fashion destination by Africans #VOOM 2016

LONDON, UK 05/16/16 · CROWDFUNDING CAMPAIGN-  Losode.com, an innovative fashion destination by...

Whom Can You Trust To Make Your Car Keys?

Toronto, Ontario 05/16/16 · Pop-A-Lock, the largest security network in North America,...

How to Fix Common Boiler Problems

Keighley, UK 05/14/16 · We ALL totally rely on our boilers to...

2016 Springtime Public Relations is Made Easy With PR Coupon

SAN FRANCISCO 05/14/16 · Spring 2016 is promising to be a time...

Fast Lane Joins the IoT Talent Consortium

Morrisville, NC 05/12/16 · - Fast Lane (www.fastlaneus.com) has accepted a role as an...

BOSS Mentors Give Local Young Women Entrepreneurial, Etiquette and Lifestyle Skills

Windsor, Ontario 05/10/16 ·  Best Opportunity to Support Self  – Manners and money...

Time to Replace Your Boiler Then Buy British with Ideal Boilers

Keighley, United Kingdom 05/05/16 · Ideal Boilers is a British Manufacturer based in...