Cancer-Killing Virus May Be The Answer For Patients With KRAS Mutated Tumors : RushPRNews - Newswire & Global Press Release Distribution

 
Bookmark and Share

Cancer-Killing Virus May Be The Answer For Patients With KRAS Mutated Tumors

July 28, 2009

Calgary, AB (RPRN) 7/28/2009--According to the American Cancer Society, about 150,000 Americans will be diagnosed with colorectal cancer in 2009.  These patients are widely treated with a drug regimen that includes a class of drugs called anti-EGFR monoclonal antibodies. The product labels on this class of drugs known as anti-EGFR monoclonal antibodies, specifically cetuximab (Erbitux®) and panitumumab (Vectibix®) have just been changed so that they will no longer be recommended for the treatment of patients with colorectal cancers having a specific mutation (KRAS).

Retrospective subset analysis of seven separate randomized trials in patients with colorectal cancers having KRAS mutations, noted a lack of benefit associated with these monoclonal antibodies. The percentage of study populations for which KRAS status was assessed range from 23 to 92%.
Patients can now be screened for EGFR and KRAS status, and patients with KRAS mutations will not be treated with therapies that are unlikely to provide benefit. Patients with just EGFR mutations or overexpression will now be treated with anti-EGFR antibodies with a higher certainty of response.  For patients with mutations in KRAS, the good news is that an alternative therapy is currently being developed for them. An oncolytic virus being developed by Oncolytics Biotech Inc. can kill cancer cells with this particular mutation and with EGFR mutations as well, and is already well-advanced into clinical trials in the U.S. and the U.K.

REOLYSIN, Oncolytics’ proprietary formulation of the reovirus, preferentially replicates in cancer cells that have an activated RAS pathway.  Approximately two-thirds of all cancers have an activated RAS pathway, including most metastatic disease.  A large number of mutations, including mutations in EGFR, Her2 or KRAS along the RAS pathway lead to RAS pathway activation.
REOLYSIN works by exploiting any mutation that leads to an activated RAS pathway. These mutations allow the virus to replicate inside tumor cells, producing thousands of copies of itself.  Eventually, the cancer cells die, releasing the virus particles, which in turn infect other cancer cells. To date, more than 280 patients with various forms of cancer have been treated with REOLYSIN in various trials in Canada, the U.S., and the U.K.  Side effects of oncolytic virus treatment are mild compared with those of chemotherapy or radiation. Some patients report a combination of mild, flu-like symptoms, which usually resolve rapidly.

While REOLYSIN is not yet available to the public, the Company has submitted a protocol to the U.S. FDA for a Phase III trial, the last step before applying for product approval.
Already underway is a U.S. Phase II clinical study using REOLYSIN in combination with paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC) with KRAS or EGFR-activated tumors.  Like colorectal cancer patients, those with mutant KRAS, or up to 20 per cent of the more than 180,000 patients diagnosed every year in the U.S. with NSCLC, do not derive benefit from EGFR-based therapies.

Together, KRAS mutated lung and colorectal cancers account for close to 100,000 newly diagnosed cases of cancer every year in the U.S.  KRAS mutated cancers are also found at high rates in leukemias and pancreatic cancers.  Advances in screening and treatment offer a prime example of the way personalized medicine can be used to tailor therapies to individuals with these cancers, possibly improving or extending life, while avoiding costly treatments that offer little to no benefit. For more information, log on to www.oncolyticsbiotech.com.

Media contact: Janet Vasquez, The Investor Relations Group, 212-825-3210 jvasquez@investorrelationsgroup.com

About the author:

Janet Vasquez, Director of Corporate Communications

About IRG

We are The Investor Relations Group (IRG), a full-service corporate communications firm that provides investor relations and public relations services to nano-, micro- and small-cap companies providing them with the equivalent in-house services of a large-cap company.

http://www.investorrelationsgroup.com

Click here to see all news from this author/company

Filed Under: Health and Fitness, Lifestyle, PRESS RELEASE, FDA- Pharmaceutical news, SCIENCE

RUSH PR NEWS newswire and press release services at rushprnews.com / Anne Howard annehowardpublicist.com

Content- Legal Responsibility - All material is copyrighted - You may repost but you MUST link back to the original post on your page and acknowledge Rush PR News as the news source. Rush PR News is not legally and/or morally responsible for content of press releases, opinions expressed or fact-checking.

Rush PR News cannot be held legally responsible for material published and distributed through its newswire service or published in its press-room and therefore cannot be sued for published material. Third-party must be contacted directly to dispute content.

Rush PR News is not the contact for material published.

RSSFeed PRESS & SOCIAL MEDIA RELEASES

Coalition Joins National Coalition for Infant Health

Washington, D.C. 06/25/15 · Newborn Foundation News: Newborn Health leaders convene in DC...

RushPRnews now offers digital news sites +Targeted News outlet Broadcast

SAN FRANCISCO/MONTREAL 06/22/15 · Your press release to be featured on at...

Save our Skies Santa Cruz Launches Petition Urging FAA to Stop the Jet Noise

Santa Cruz, California 06/21/15 · Outraged Citizens fight FAA's NextGenprogram to reclaim quality...

Ultraseal International makes casting impregnation even easier with fully automated two-stage process

Dusseldorf, Germany 06/17/15 · Ultraseal International is living up to its global...

Army Officials and Ameresco Join to Commemorate Completion of Energy Efficiency and Solar Project

FRAMINGHAM, Mass. & ADELPHI, Md. 06/16/15 · Army Officials and Ameresco Join to Commemorate Completion...

Ultraseal International celebrates second exporting award this year

Birmingham, West Midlands, UK 06/16/15 · Ultraseal International is celebrating a double success after...

The American radio host, Ed Tyll issues death threat, alleges a French-Canadian publisher

Montreal, Quebec, Canada 06/15/15 · On June 5, the controversial radio host, Edward...

Planwise: Best Mortgage Calculator Since 1993

San Francisco, CA 06/09/15 · Planwise Launches Pinterest Style Mortgage Calculator  Planwise launches PlanwiseConnect,...

Israel’s Start Tel Aviv offers global opportunity for Canadian tech startups

Ottawa,Canada 06/09/15 · Israel’s Start Tel Aviv offers global opportunity for...

Demand for Independence of Punjab Echoes in San Francisco

San Francisco 06/08/15 ·  Thousands of North American Sikhs converged in downtown...

World Renowned Casting Director Appointed to Eagle Arts Academy Board of Directors

Los Angeles, CA 06/06/15 · Eagle Arts Academy is pleased to announce that...

MultiClonal Therapeutics Researchers Report Today Breakthrough in Cloning Human “Ground State” Stem Cells

Farmington,CT 06/05/15 · An international consortium including investigators at MultiClonal Therapeutics,...

Time to increase your public relations impact

SAN FRANCISCO 06/04/15 ·                 Your « SPRING2015-2 » Coupon is here! And with it...

Financial Fraud Lengthy Prison Term for Advance Fee Fraudster

Washington, DC 06/02/15 · Like many successful con men, William C. Lange...